27-DEOXYACTEIN
Synonym(s):26-Deoxyactein
- CAS NO.：264624-38-6
- Empirical Formula: C37H56O10
- Molecular Weight: 660.83
- MDL number: MFCD07783721
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:36
What is 27-DEOXYACTEIN?
Description
23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa). It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.
The Uses of 27-DEOXYACTEIN
27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.
What are the applications of Application
27-Deoxyactein is has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis
Definition
ChEBI: 26-Deoxyactein is a triterpenoid. It has a role as a metabolite.
Properties of 27-DEOXYACTEIN
| Melting point: | 253～254℃ |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Very Slightly), Pyridine (Slightly) |
| form | Solid |
| pka | 13.03±0.70(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for 27-DEOXYACTEIN
Computed Descriptors for 27-DEOXYACTEIN
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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