2,6-Pyridinedimethanol

Chemical properties

light yellow to beige crystalline powder

The Uses of 2,6-Pyridinedimethanol

2,6-Pyridinedimethanol can be used as a quantum dot solution for photoelectric device and biomedicine and also a ligand to synthesize a variety of metal complexes and catalysts.

Preparation

The preparation of 2,6-Pyridinedimethanol is as follows:2640g of 2,6-dibromomethylpyridine, 3L of 30% aqueous sodium hydroxide solution, and 10L of ethanol were placed in a 20L reaction flask. Turn on the agitation. The reaction solution was heated to reflux and the reaction was kept for 5h. The TLC to intermediate state reaction is complete. The reaction solution is cooled to room temperature, plus into 20L of ice water, stir for 20min. The aqueous phase was extracted twice with 10L of dichloromethane and the organic phases were combined. The organic phase is concentrated under reduced pressure to dry, a solid of 1232g was obtained, the yield was 88.6%, and the liquid phase was 98%.

Synthesis

The method preparing 2,6-pyridine dimethanol:

2,6-lutidines mixes with a certain amount of water, controls at a certain temperature, is dividedly in some parts potassium permanganate, control stoichiometric number hour at a certain temperature, being down to room temperature, sucking filtration after reacting completely, acidification of filtrate obtains product 2,6-pyridinedicarboxylic acid, this compound with sodium borohydride/iodine reduction system, post-treated obtains target product 2,6-pyridine dimethanol.