2,6-DI-O-METHYL-BETA-CYCLODEXTRIN

Synonym(s):2,6-Di-O-methyl-β-cyclodextrin;Dimethyl β-cyclodextrin;DM-β-CD;DM‐β‐CyD;heptakis-(2,6-O-Dimethyl)-β-cyclodextrin

CAS NO.：51166-71-3
Empirical Formula: C56H98O35
Molecular Weight: 1331.36
MDL number: MFCD00011616
EINECS: 1312995-182-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

2,6-DI-O-METHYL-BETA-CYCLODEXTRIN Structural

What is 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN?

Chemical properties

White to faintly yellow crystalline powder

The Uses of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN

Induces the release of cholesterol from cholesterol-rich lipid rafts located on the surface of cells, making it a good agent for removing cholesterol from processed foods

The Uses of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN

Reactant involved in:

Physicochemical studies of inclusion complexes
Probing diffusion and single molecule interactions with reconstituted membrane proteins
Interactions with micelles causing micellar rupture
Studying cellular transport, used as a cell penetration enhancer
Physicochemical and biopharmaceutical improvement of drugs particularly with solubilization and stability
Interactions with cholesterol

What are the applications of Application

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a cholesterol sequestering cyclodextrin preparation

General Description

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a hydrophilic derivative of cyclodextrin that possesses the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be utilized to increase the dissolution and bioavailability of weakly water-soluble pharmaceutical compounds.

Properties of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN

Melting point:	298-310 °C
Boiling point:	1203.6±65.0 °C(Predicted)
Density	1.40±0.1 g/cm3(Predicted)
refractive index	163 ° (C=1, H2O)
storage temp.	Sealed in dry,Room Temperature
solubility	H₂O: soluble
pka	11.63±0.70(Predicted)
form	Crystalline Powder
color	White to faintly yellow
optical activity	[α]20/D +158±3°, c = 10% in H2O
Water Solubility	212.6g/L(cold water)
BRN	1679144
CAS DataBase Reference	51166-71-3

Safety information for 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.