2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
Synonym(s):2,6-Di-O-methyl-β-cyclodextrin;Dimethyl β-cyclodextrin;DM-β-CD;DM‐β‐CyD;heptakis-(2,6-O-Dimethyl)-β-cyclodextrin
- CAS NO.：51166-71-3
- Empirical Formula: C56H98O35
- Molecular Weight: 1331.36
- MDL number: MFCD00011616
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 17:01:59
What is 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN?
Chemical properties
White to faintly yellow crystalline powder
The Uses of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
Induces the release of cholesterol from cholesterol-rich lipid rafts located on the surface of cells, making it a good agent for removing cholesterol from processed foods
The Uses of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
Reactant involved in:
- Physicochemical studies of inclusion complexes
- Probing diffusion and single molecule interactions with reconstituted membrane proteins
- Interactions with micelles causing micellar rupture
- Studying cellular transport, used as a cell penetration enhancer
- Physicochemical and biopharmaceutical improvement of drugs particularly with solubilization and stability
- Interactions with cholesterol
What are the applications of Application
Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a cholesterol sequestering cyclodextrin preparation
General Description
Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a hydrophilic derivative of cyclodextrin that possesses the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be utilized to increase the dissolution and bioavailability of weakly water-soluble pharmaceutical compounds.
Properties of 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
| Melting point: | 298-310 °C |
| Boiling point: | 1203.6±65.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| refractive index | 163 ° (C=1, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: soluble |
| pka | 11.63±0.70(Predicted) |
| form | Crystalline Powder |
| color | White to faintly yellow |
| optical activity | [α]20/D +158±3°, c = 10% in H2O |
| Water Solubility | 212.6g/L(cold water) |
| BRN | 1679144 |
| CAS DataBase Reference | 51166-71-3 |
Safety information for 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,6-DI-O-METHYL-BETA-CYCLODEXTRIN
| InChIKey | QGKBSGBYSPTPKJ-UZMKXNTCSA-N |
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