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HomeProduct name list25-DESACETYL RIFAMPICIN

25-DESACETYL RIFAMPICIN

25-DESACETYL RIFAMPICIN Structural

What is 25-DESACETYL RIFAMPICIN?

Description

25-desacetyl rifampicin, also known as 25-deacetyl-rifampicin, is the main metabolite of rifampicin. It has partial activity. Rifampicin mainly treats various forms of tuberculosis. High-Performance Liquid Chromatographic can be used to determine the metabolism of rifampicin in the body by checking the concentration of 25-desacetyl rifampicin in the urine or blood of tuberculosis patients[1-3].

Chemical properties

Dark Red Solid

The Uses of 25-DESACETYL RIFAMPICIN

A metabolite of Rifampicin.

What are the applications of Application

25-Desacetyl Rifampicin is a metabolite of Rifampicin

References

[1]Chik Z, et al. A bioequivalence comparison of two formulations of rifampicin (300- vs 150-mg capsules): An open-label, randomized, two-treatment, two-way crossover study in healthy volunteers. Clinical Therapeutics, 2011.
[2] Mohan B, et al.Evaluation of the recently reported USP gradient HPLC method for analysis of anti-tuberculosis drugs for its ability to resolve degradation products of rifampicin. Journal of Pharmaceutical and Biomedical Analysis, 2003; 31: 607-612.
[3] Lily, et al. The influence of mutation gene rpoB of Mycobacterium tuberculosis cluster I (507-534) on the elimination 25-desacetyl rifampicin in urine of tuberculosis subjects. IOP Conference Series: Earth and Environmental Science, 2018; 1755-1315.

Properties of 25-DESACETYL RIFAMPICIN

Melting point: >300°C
Boiling point: 943.1±65.0 °C(Predicted)
Density  1.35±0.1 g/cm3(Predicted)
storage temp.  Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 4.96±0.70(Predicted)
color  Dark Red to Black
Stability: Light Sensitive

Safety information for 25-DESACETYL RIFAMPICIN

Computed Descriptors for 25-DESACETYL RIFAMPICIN

InChIKey KUJZTIJOBQNKDR-ACYBWPGYNA-N

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