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HomeProduct name list2,4,6-TRIMETHYLPHENYL ISOCYANATE

2,4,6-TRIMETHYLPHENYL ISOCYANATE

2,4,6-TRIMETHYLPHENYL ISOCYANATE Structural

What is 2,4,6-TRIMETHYLPHENYL ISOCYANATE?

The Uses of 2,4,6-TRIMETHYLPHENYL ISOCYANATE

2,4,6-Trimethylphenyl isocyanate is used as an organic chemical synthesis intermediate.

Preparation

A solution of Boc2O (619 mg, 2.84 mmol) in acetonitrile (2 mL) was treated successively with a solution of 4-dimethylaminopyridine (33 mg, 0.27 mmol) in acetonitrile (2 mL) and a solution of 348 (365 mg, 2.7 mmol) in acetonitrile (2 mL). The reaction mixture was stirred vigorously for 10 min. After the addition of concentrated sulfuric acid in acetonitrile (40% solution, ρ= 1:03 g cm-3, 0.47 mL), the resulting mixture was stirred for 5 min. Water (0.47 mL) was then added, and the mixture was stirred for a further 5 min. The reaction mixture was then poured into an equal volume of water. The solution was extracted three times with hexane, and the combined hexane layers were dried over magnesium sulfate. Removal of the solvent in vacuo afforded mesityl isocyanate 349 (420 mg, 97%) as colorless crystals; mp 42 °C.

Properties of 2,4,6-TRIMETHYLPHENYL ISOCYANATE

Melting point: 44-48 °C(lit.)
Boiling point: 218-220°C
Flash point: 220 °F
storage temp.  2-8°C
Water Solubility  It hydrolyzes in water.
Sensitive  Moisture Sensitive
BRN  2085601
CAS DataBase Reference 2958-62-5

Safety information for 2,4,6-TRIMETHYLPHENYL ISOCYANATE

Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H300:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H330:Acute toxicity,inhalation
H334:Sensitisation, respiratory
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P320:Specific treatment is urgent (see … on this label).
P330:Rinse mouth.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2,4,6-TRIMETHYLPHENYL ISOCYANATE

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