2,4,6-Triisopropylbenzene-sulfonyl azide

Synonym(s):2,4,6-Triisopropylphenylsulfonyl azide;2,4,6-Tris(1-methylethyl)-benzenesulfonyl azide;Trisyl azide solution

CAS NO.：36982-84-0
Empirical Formula: C15H23N3O2S
Molecular Weight: 309.43
MDL number: MFCD00859286
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-14 15:27:00

2,4,6-Triisopropylbenzene-sulfonyl azide Structural

What is 2,4,6-Triisopropylbenzene-sulfonyl azide?

Chemical properties

White wet solid

The Uses of 2,4,6-Triisopropylbenzene-sulfonyl azide

Reagent for:• ;Stereoselective diversity-oriented synthesis of functionalized saccharides1• ;Meyer′s lactamization2Reagent for synthesis of:• ;Antidote to anthrax lethal factor intoxication3• ;Bacterial RNA polymerase inhibitor4• ;Bicyclic extended dipeptide surrogates5• ;Single enantiomers of mycobacterial keomycolic acids6

The Uses of 2,4,6-Triisopropylbenzene-sulfonyl azide

2,4,6-Triisopropylbenzenesulfonyl azide is used as a reagent for diazo transfer to ketones, e.g. under phase-transfer conditions, giving better yields of sterically-hindered ?-diazo ketones than other methods. It is also used for azide transfer to potassium enolates (KHMDS) to form the ?-azido derivatives.

Properties of 2,4,6-Triisopropylbenzene-sulfonyl azide

Melting point:	39-44 °C
refractive index	n20/D1.499
Flash point:	4℃
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	White to Off-White
Water Solubility	Insoluble in water.
BRN	2391566
CAS DataBase Reference	36982-84-0(CAS DataBase Reference)

Safety information for 2,4,6-Triisopropylbenzene-sulfonyl azide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H225:Flammable liquids H302:Acute toxicity,oral H304:Aspiration hazard H315:Skin corrosion/irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H373:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P308+P313:IF exposed or concerned: Get medical advice/attention.