2,4,6-TRIFLUOROBENZYL AMINE
- CAS NO.:214759-21-4
- Empirical Formula: C7H6F3N
- Molecular Weight: 161.12
- MDL number: MFCD00236317
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-24 16:40:13
What is 2,4,6-TRIFLUOROBENZYL AMINE?
The Uses of 2,4,6-TRIFLUOROBENZYL AMINE
Used to prepare dyes. Industrially used in natural gas and refinery process streams. They also are used in polymer industry as monomers. Amines find use as additives for lubricating oils, engine fuels, and asphalt, and are producers of ethanolamines.
The Uses of 2,4,6-TRIFLUOROBENZYL AMINE
2,4,6-Trifluorobenzylamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Put into 50 gram 2 into 1000ml autoclave, 4,6- trifluorobenzonitriles, 2.5 grams of raney-ni, 75 gram 25% of ammonia, 500 grams of methanol, control temperature to be 90 DEG C, and mixing speed is 350r/min, are passed through hydrogen hydrogenation, hydrogenation pressure 1mpa, logical hydrogen time 8 Hour reaction terminates, filtering catalyst raney-ni, the methanol in distillation gained filtrate, and distillation terminates addition dichloromethane extraction Take, extract elder generation normal pressure concentrated solvent, then vacuum distillation product, obtain 43.6 grams of product, 2,4,6- trifluoromethyl benzonitrile amine contents 99%, yield is calculated as 85% with 2,4,6- trifluorobenzonitriles.
Properties of 2,4,6-TRIFLUOROBENZYL AMINE
Boiling point: | 165℃ |
Density | 1.320 |
Flash point: | 63℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 8.16±0.10(Predicted) |
color | Colourless |
Water Solubility | Slightly Soluble in water (1.2 g/L) (25°C). |
Sensitive | Air Sensitive |
Stability: | Air Sensitive |
Safety information for 2,4,6-TRIFLUOROBENZYL AMINE
Signal word | Warning |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2,4,6-TRIFLUOROBENZYL AMINE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B 2,2-diethoxyethanethioamide Tubulysin F Tubulysin E Tubulysin D 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Methyl 4-amino-3-(piperidin-1-yl)benzoate 5-Aminophthalazine 1-(4-Fluorophenyl)piperidin-2-one (1-Isopropyl-1H-pyrazol-5-yl)boronic acid Methyl 4-amino-3-(dihexylamino)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 3-bromo-5-fluorobenzaldehyde Zanubrutinib (-)-1-Phenyl ethane sulfonic acidRelated products of tetrahydrofuran
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