2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE

Synonym(s):(2,4-Dimethoxyphenyl)-(4-hydroxyphenyl)methanone;2,4-Dimethoxy-4′-hydroxybenzophenone

CAS NO.：41351-30-8
Empirical Formula: C15H14O4
Molecular Weight: 258.27
MDL number: MFCD00137850
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE Structural

What is 2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE?

Chemical properties

2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE is white to off-white powder

The Uses of 2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE

2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE is used for solid-phase peptide synthesis with FMOC strategy

What are the applications of Application

4′-Hydroxy-2,4-dimethoxybenzophenone is a linker employed for solid-phase peptide synthesis

Preparation

Preparation by Friedel–Crafts acylation of resorcinol dimethyl ether with p-hydroxybenzoic acid,
? in the presence of zinc chloride and phosphorous oxychloride at 60–65° for 1.5 h (71%) or in nitrobenzene at 60° for 2–3 h;
? in the presence of polyphosphoric acid.

Properties of 2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE

Melting point:	138-142 °C (lit.)
Boiling point:	467.9±45.0 °C(Predicted)
Density	1.206±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	soluble in Methanol
form	Powder
pka	7.73±0.15(Predicted)
color	Off-white to white
BRN	2508320
CAS DataBase Reference	41351-30-8(CAS DataBase Reference)

Safety information for 2,4-DIMETHOXY-4'-HYDROXYBENZOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.