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HomeProduct name list2,4-Dihydroxybenzophenone

2,4-Dihydroxybenzophenone

Synonym(s):2,4-Dihydroxybenzophenone;BP-1;DHB;EIF4EBP1;PHAS-I

  • CAS NO.:131-56-6
  • Empirical Formula: C13H10O3
  • Molecular Weight: 214.22
  • MDL number: MFCD00002277
  • EINECS: 205-029-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
2,4-Dihydroxybenzophenone Structural

What is 2,4-Dihydroxybenzophenone?

Chemical properties

yellow crystalline powder

The Uses of 2,4-Dihydroxybenzophenone

2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.

The Uses of 2,4-Dihydroxybenzophenone

Ultraviolet light absorber, especially in paints and plastics.

The Uses of 2,4-Dihydroxybenzophenone

Novel mordent and disperse azo dyes were prepared by the coupling of various diazo solutions of aromatic amines with 2, 4-dihydroxybenzophenone. The ultraviolet absorbing monomers were synthesized by reaction of 2, 4-dihydroxybenzophenone with glycidyl acrylate and glycidyl methacrylate. Two new polymerizable stabilizers, 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and corresponding methacrylate (BPBHMA), were synthesized and characterized from 2,4-Dihydroxybenzophenone. a polymerizable UV-stabilizer, 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), was synthesized using 2, 4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA).

What are the applications of Application

2,4-Dihydroxybenzophenone is a useful chemical for proteomics research

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Definition

ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.

Contact allergens

BZP-1 is used, for example, in paints, plastics, and nail varnishes.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

Properties of 2,4-Dihydroxybenzophenone

Melting point: 144.5-147 °C(lit.)
Boiling point: 194 °C (1 mmHg)
Density  1,32 g/cm3
vapor pressure  0Pa at 25℃
refractive index  1.5090 (estimate)
Flash point: 125 °C
storage temp.  Store below +30°C.
solubility  Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
pka 7.72±0.35(Predicted)
form  Crystalline Powder
color  Yellow
PH 5 (10g/l, H2O, 20℃)(slurry)
Water Solubility  insoluble
Merck  14,1106
BRN  1311566
CAS DataBase Reference 131-56-6(CAS DataBase Reference)
NIST Chemistry Reference Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA Substance Registry System Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)

Safety information for 2,4-Dihydroxybenzophenone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H319:Serious eye damage/eye irritation
H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for 2,4-Dihydroxybenzophenone

InChIKey ZXDDPOHVAMWLBH-UHFFFAOYSA-N

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