2,4-Dihydroxybenzophenone

Synonym(s):2,4-Dihydroxybenzophenone;BP-1;DHB;EIF4EBP1;PHAS-I

CAS NO.：131-56-6
Empirical Formula: C13H10O3
Molecular Weight: 214.22
MDL number: MFCD00002277
EINECS: 205-029-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is 2,4-Dihydroxybenzophenone?

Chemical properties

yellow crystalline powder

The Uses of 2,4-Dihydroxybenzophenone

2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.

The Uses of 2,4-Dihydroxybenzophenone

Ultraviolet light absorber, especially in paints and plastics.

The Uses of 2,4-Dihydroxybenzophenone

Novel mordent and disperse azo dyes were prepared by the coupling of various diazo solutions of aromatic amines with 2, 4-dihydroxybenzophenone. The ultraviolet absorbing monomers were synthesized by reaction of 2, 4-dihydroxybenzophenone with glycidyl acrylate and glycidyl methacrylate. Two new polymerizable stabilizers, 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and corresponding methacrylate (BPBHMA), were synthesized and characterized from 2,4-Dihydroxybenzophenone. a polymerizable UV-stabilizer, 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), was synthesized using 2, 4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA).

What are the applications of Application

2,4-Dihydroxybenzophenone is a useful chemical for proteomics research

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Definition

ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.

Contact allergens

BZP-1 is used, for example, in paints, plastics, and nail varnishes.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

Properties of 2,4-Dihydroxybenzophenone

Melting point:	144.5-147 °C(lit.)
Boiling point:	194 °C (1 mmHg)
Density	1,32 g/cm³
vapor pressure	0Pa at 25℃
refractive index	1.5090 (estimate)
Flash point:	125 °C
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
pka	7.72±0.35(Predicted)
form	Crystalline Powder
color	Yellow
PH	5 (10g/l, H2O, 20℃)(slurry)
Water Solubility	insoluble
Merck	14,1106
BRN	1311566
CAS DataBase Reference	131-56-6(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA Substance Registry System	Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)

Safety information for 2,4-Dihydroxybenzophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.