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HomeProduct name list2,4-Dichloro-6-methylpyrimidine

2,4-Dichloro-6-methylpyrimidine

  • CAS NO.:5424-21-5
  • Empirical Formula: C5H4Cl2N2
  • Molecular Weight: 163
  • MDL number: MFCD00006064
  • EINECS: 226-563-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-12 16:52:33
2,4-Dichloro-6-methylpyrimidine  Structural

What is 2,4-Dichloro-6-methylpyrimidine ?

Chemical properties

White to Light Yellow Powder

The Uses of 2,4-Dichloro-6-methylpyrimidine

2,4-Dichloro-6-methylpyrimidine is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.

General Description

2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

Properties of 2,4-Dichloro-6-methylpyrimidine

Melting point: 44-47 °C (lit.)
Boiling point: 219 °C (lit.)
Density  1.5462 (rough estimate)
refractive index  1.6300 (estimate)
Flash point: >230 °F
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Chloroform (Very Slightly, Heated, Sonicated), DMSO (Sparingly, Heated)
pka -2.12±0.30(Predicted)
form  powder to crystal
color  White to Orange to Green
Water Solubility  Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.
BRN  114295
CAS DataBase Reference 5424-21-5(CAS DataBase Reference)
EPA Substance Registry System Pyrimidine, 2,4-dichloro-6-methyl- (5424-21-5)

Safety information for 2,4-Dichloro-6-methylpyrimidine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2,4-Dichloro-6-methylpyrimidine

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