2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE

CAS NO.：19752-61-5
Empirical Formula: C12H19BrN2O2
Molecular Weight: 303.2
MDL number: MFCD01927527
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE?

The Uses of 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE

5-Bromo-2,4-bis(1,1-dimethylethoxy)pyrimidine is an intermediate in the synthesis of β-Pseudouridine (O839607), an isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA.

Synthesis

5-Bromo-2,4-dichloropyrimidine (10.0 mmol, 2.28 g) is dissolved in dry THF (50 mL). Then a solution of sodium tert-butoxide (25.0 mmol, 2.40 g) in THF (100 mL) is added dropwise at rt and the reaction mixture stirred for 5 h. The reaction is quenched with water (50 mL) and extracted with EtOAc (3 x 50 mL). Purification by flash chromatography yielded the desired product 5 as colorless solid (2.79 g, 92%). 5-Bromo-2,4-di-tert-butoxypyrimidine 5 ,Yield 2.79 g, 92%.

Properties of 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE

Melting point:	58-61°C
Boiling point:	352.0±45.0 °C(Predicted)
Density	1.267±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DCM, Ethyl Acetate, Methanol
form	Solid
pka	1.73±0.29(Predicted)
color	White

Safety information for 2,4-DI-(TERT-BUTOXY)-5-BROMOPYRIMIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.