22(R)-HYDROXYCHOLESTEROL
Synonym(s):22α-Hydroxycholesterol;5-Cholestene-3β,22(R)-diol;5-Cholestene-3β,22[R]-diol;5-cholestene-3β,22-diol; 22-hydroxycholest-5-en-3-ol
- CAS NO.:17954-98-2
- Empirical Formula: C27H46O2
- Molecular Weight: 402.65
- MDL number: MFCD00070042
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:14
What is 22(R)-HYDROXYCHOLESTEROL?
Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-
The Uses of 22(R)-HYDROXYCHOLESTEROL
Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
The Uses of 22(R)-HYDROXYCHOLESTEROL
The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.
What are the applications of Application
22(R)-hydroxycholesterol is an endogenous LXR agonist
Definition
ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.
General Description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.
Properties of 22(R)-HYDROXYCHOLESTEROL
Melting point: | 171-174°C |
Boiling point: | 513.1±23.0 °C(Predicted) |
Density | 1.03±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 15.01±0.20(Predicted) |
color | White to Off-White |
Safety information for 22(R)-HYDROXYCHOLESTEROL
Computed Descriptors for 22(R)-HYDROXYCHOLESTEROL
InChIKey | RZPAXNJLEKLXNO-QUOSNDFLSA-N |
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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