22(R)-HYDROXYCHOLESTEROL
Synonym(s):22α-Hydroxycholesterol;5-Cholestene-3β,22(R)-diol;5-Cholestene-3β,22[R]-diol;5-cholestene-3β,22-diol; 22-hydroxycholest-5-en-3-ol
- CAS NO.:17954-98-2
- Empirical Formula: C27H46O2
- Molecular Weight: 402.65
- MDL number: MFCD00070042
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:14
What is 22(R)-HYDROXYCHOLESTEROL?
Description
The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-
The Uses of 22(R)-HYDROXYCHOLESTEROL
Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.
The Uses of 22(R)-HYDROXYCHOLESTEROL
The 22R-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.
What are the applications of Application
22(R)-hydroxycholesterol is an endogenous LXR agonist
Definition
ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.
General Description
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.
Biochem/physiol Actions
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression.
Properties of 22(R)-HYDROXYCHOLESTEROL
Melting point: | 171-174°C |
Boiling point: | 513.1±23.0 °C(Predicted) |
Density | 1.03±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 15.01±0.20(Predicted) |
color | White to Off-White |
Safety information for 22(R)-HYDROXYCHOLESTEROL
Computed Descriptors for 22(R)-HYDROXYCHOLESTEROL
InChIKey | RZPAXNJLEKLXNO-QUOSNDFLSA-N |
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen 4-((2-isopropoxyethoxy)methyl)phenol 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid 1,2,3,4-Tetrahydrocarbazol-4-one Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride Methyl Di Chloride (Mdc) 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/Related products of tetrahydrofuran
You may like
-
22(R)-Hydroxycholesterol CAS 17954-98-2View Details
17954-98-2 -
22(R)-hydroxycholesterol CAS 17954-98-2View Details
17954-98-2 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
2, 4-Pyrimidinediamine 3-Oxide 99%View Details
74638-76-9 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
(−)-Dip-Chloride 85116-37-6 99%View Details
85116-37-6