2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
Synonym(s):Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem;M50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
- CAS NO.:54135-60-3
- Empirical Formula: C13H16O4
- Molecular Weight: 236.26
- MDL number: MFCD00192291
- EINECS: 258-989-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)?
The Uses of 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
What are the applications of Application
Apoptosis Inhibitor is a cell-permeable inhibitor of apoptosis induction
Definition
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone.
Biological Activity
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]
References
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45.
Properties of 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
Melting point: | 132.5-133.5 °C |
Boiling point: | 461.2±40.0 °C(Predicted) |
Density | 1.227±0.06 g/cm3(Predicted) |
storage temp. | +2C to +8C |
solubility | Soluble in DMSO or ethanol |
form | Off-white solid |
pka | 4.87±0.25(Predicted) |
Sensitive | Light Sensitive |
Safety information for 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
Computed Descriptors for 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE)
New Products
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