20-HETE
Synonym(s):20-HETE;20-Hydroxyarachidonic acid
- CAS NO.：79551-86-3
- Empirical Formula: C20H32O3
- Molecular Weight: 320.47
- MDL number: MFCD00171542
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 21:27:52
What is 20-HETE?
The Uses of 20-HETE
20-HETE is a cytochrome P450 (CYP450) metabolite that may play an autacoid role in cerebral and renal vasculature.
Definition
ChEBI: A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20.
Biochem/physiol Actions
20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.
Properties of 20-HETE
| Boiling point: | 482.0±33.0 °C(Predicted) |
| Density | 0.985±0.06 g/cm3(Predicted) |
| Flash point: | 14℃ |
| storage temp. | -20°C |
| solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml |
| form | Powder |
| pka | 4.75±0.10(Predicted) |
Safety information for 20-HETE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 20-HETE
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