20-CARBOXY-LEUKOTRIENE B4

Synonym(s):20-Carboxy-LTB4

CAS NO.：80434-82-8
Empirical Formula: C20H30O6
Molecular Weight: 366.45
MDL number: MFCD00065857
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:42

What is 20-CARBOXY-LEUKOTRIENE B4?

Description

20-carboxy LTB₄ is a metabolite of LTB₄ in human neutrophils. In human leukocytes, LTB₄ is inactivated by the enzyme LTB₄ 20-hydroxylase. The resulting 20-hydroxy LTB₄ is further oxidized to 20-carboxy LTB₄. LTB₄ metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB₄ along with other ω-oxidation products. The biological activity of 20-carboxy LTB₄ is only about 2.6% compared to that of LTB₄ in causing PMNL degranulation.

The Uses of 20-CARBOXY-LEUKOTRIENE B4

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

What are the applications of Application

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways

Definition

ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.

Properties of 20-CARBOXY-LEUKOTRIENE B4

Boiling point:	588.3±50.0 °C(Predicted)
Density	1.151±0.06 g/cm3(Predicted)
Flash point:	14℃
storage temp.	−20°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
form	Liquid
pka	4.66±0.10(Predicted)
color	Colorless to light yellow

Safety information for 20-CARBOXY-LEUKOTRIENE B4

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.