2-VALERYLOXYBENZOIC ACID
Synonym(s):2-Valeryloxybenzoic acid;Valerylsalicylic acid;vsa
- CAS NO.:64206-54-8
- Empirical Formula: C12H14O4
- Molecular Weight: 222.24
- MDL number: MFCD00041466
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 2-VALERYLOXYBENZOIC ACID?
The Uses of 2-VALERYLOXYBENZOIC ACID
Valeryl salicylate is a selective inhibitor of Cox-1.
What are the applications of Application
Valeryl salicylate is a selective inhibitor of Cox-1
Definition
ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.
Biological Activity
valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].
References
[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.
Properties of 2-VALERYLOXYBENZOIC ACID
Melting point: | 86-87 °C(lit.) |
Boiling point: | 357.6±25.0 °C(Predicted) |
Density | 1.175±0.06 g/cm3(Predicted) |
storage temp. | Room temperature |
solubility | DMSO: 24 mL/mL |
pka | 3.01±0.36(Predicted) |
form | A crystalline solid |
color | white |
Safety information for 2-VALERYLOXYBENZOIC ACID
Computed Descriptors for 2-VALERYLOXYBENZOIC ACID
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