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HomeProduct name list2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

Synonym(s):BTMG

2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE Structural

What is 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE?

The Uses of 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

Preparation

To an ovendried, 500-mL, three-necked, round-bottomed flask, equipped with a nitrogen inlet with gas bubbler, magnetic stirring bar, thermometer, condenser, and a 250-mL dropping funnel, were added triphosgene (14.8 g, 0.05 mol) and anhydrous toluene (120 mL). The mixture was kept under argon and cooled to ca. 10 C° with the aid of an external ice bath. A solution of N,N,N,N-tetramethylurea (18.0 mL, 0.15 mol) in dry toluene (50 mL) was then slowly added over a period of 30 min. After completion of the addition, the mixture was allowed to warm to ambient temperature, and stirring was continued for a further 1 h. During this time, a white precipitate formed, consisting of the Vilsmeier salt. Then, tert-butylamine (47.3 mL, 0.45 mol) was slowly added to the mixture over a period of 30 min. After completion of the addition, the mixture was heated under reflux for 5 h and then cooled to room temperature. Anhydrous diethyl ether (200 mL) was added and the white precipitate was quickly removed by filtration. This precipitate had to be collected as quickly as possible to avoid hydrolysis to the starting urea. The precipitate turns pale-yellow if hydrolysis is occurring. In some instances, additional diethyl ether (300 mL) was needed to ensure complete transfer of the solids to the filtration apparatus. The precipitate was washed with a further quantity of anhydrous diethyl ether (300 mL) (the filtrate must be colorless, indicating that all impurities have been removed) and immediately dissolved in aqueous 25% sodium hydroxide solution (100 mL). The mixture was then extracted with diethyl ether (3 × 300 mL). The combined organic layers were dried (potassium carbonate), filtered, and the solvent was removed under reduced pressure. The resulting colorless liquid was purified by distillation (bp 88–89 C°/36 mmHg) to afford 18.7 g (73%) of 2-tertbutyl- 1,1,3,3-tetramethylguanidine 1779.

General Description

2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton′s base) is an excellent alternative to traditional inorganic bases for promoting the coupling reaction.

Properties of 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

Boiling point: 88-89 °C/43 mmHg (lit.)
Density  0.85
refractive index  n20/D 1.457
Flash point: 65 °C
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
form  clear liquid
pka 13.81±0.70(Predicted)
color  Colorless to Light yellow
BRN  2352408

Safety information for 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H314:Skin corrosion/irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-TERT-BUTYL-1,1,3,3-TETRAMETHYLGUANIDINE

InChIKey YQHJFPFNGVDEDT-UHFFFAOYSA-N

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