2-Pyridylacetonitrile

CAS NO.：2739-97-1
Empirical Formula: C7H6N2
Molecular Weight: 118.14
MDL number: MFCD00006346
EINECS: 220-364-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-18 18:37:42

What is 2-Pyridylacetonitrile?

Chemical properties

Colorless to yellow to orange to brown liquid

The Uses of 2-Pyridylacetonitrile

2-Pyridineacetonitrile is used as a pharmaceutical intermediate. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

General Description

2-Pyridylacetonitrile undergoes coupling with aromatic diazonium salts to yield arylhydrazones. It also undergoes condensation with active malonic esters to yield 1-cyano-3-substituted 2-hydroxyquinolizin-4-ones. Acylation reaction of 2-pyridylacetonitrile with hot acetic anhydride has been reported.

Properties of 2-Pyridylacetonitrile

Melting point:	23-25°C
Boiling point:	76-77 °C/2 mmHg (lit.)
Density	1.059 g/mL at 25 °C (lit.)
refractive index	n20/D 1.525(lit.)
Flash point:	201 °F
solubility	soluble in Chloroform, Methanol
pka	3.22±0.12(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Yellow to Orange
Water Solubility	Miscible with water.
BRN	111215
CAS DataBase Reference	2739-97-1(CAS DataBase Reference)
NIST Chemistry Reference	2-Pyridylacetonitrile(2739-97-1)

Safety information for 2-Pyridylacetonitrile

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.