2-Phenylbenzimidazole-5-sulfonic acid

Toxicity

Dermal LD50 in rat is > 3000 mg/kg and oral LD50 in rat is > 16000 mg/kg .

Chemical properties

white fine crystalline powder

The Uses of 2-Phenylbenzimidazole-5-sulfonic acid

phenylbenzimidazole sulfonic acid (2-phenyl-5-benzimidazolesulfonic acid; 2-phenylbenzimidazole-5-sulfonic acid, ensulizole) is one of 21 FDA-approved sunscreen chemicals for uVB absorption. It has an approved usage level of up to 4 percent in the united States and up to 8 percent in the european union. When combined with a proper base, it becomes a water-soluble sunscreen. It exhibits a very effective use level versus SPF relationship when compared to other sunscreen chemicals. In addition, when combined with other uVB absorbers, it seems to significantly boost SPF. It can also help protect a product from deterioration when exposed to uV light. Also considered excellent for use in clear sunscreen gels.

The Uses of 2-Phenylbenzimidazole-5-sulfonic acid

ensulizole is one of the chemical names for phenylbenzimidazole sulfonic acid. used as a sunscreen ingredient and also to protect a product from deterioration caused by uV light.

The Uses of 2-Phenylbenzimidazole-5-sulfonic acid

Phenylbenzimidazole sulfonic acid or ensulizole is a water-soluble UVB absorber that can be utilized in the water phase of emulsion systems, in contrast to most oil-soluble sunscreen ingredients, allowing for a less greasy, more aesthetically pleasing formulation such as a daily use moisturizer containing sunscreen. Phenylbenzimidazole sulfonic acid boosts the SPF of organic and inorganic sunscreens. It can also be used in clear gels owing to its water solubility.

Indications

Indicated to be used as an UV-B-absorbing molecule in sunscreen formulations.

Background

Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly used in products formulated to feel light and less oily . It was demonstrated by studies that ensulizole treatment provided protection against cyclobutane pyrimidine dimers and photosensitized the formation of oxidized guanine bases after UV-A or UV-B exposure . According to the FDA, the maximal approved concentration of ensulizole is 148 mM although concentrations ranging between 74 and 148mM can be found in commercial sunscreen products .

What are the applications of Application

2-Phenyl-5-benzimidazolesulfonic acid is an absorber of UV

Definition

ChEBI: Ensulizole is a member of benzimidazoles.

General Description

2-Phenyl-5-benzimidazolesulfonic acid has been reported as a UV filter and its removal from aerobically treated gray water by ozonation and adsorption onto activated carbon has been reported. It is a xenobiotic compound detected in gray water from houses and effluents of the biological treatment systems (aerobic, anaerobic, and combined anaerobic+aerobic).

Flammability and Explosibility

Non flammable

Pharmacokinetics

Ensulizole is a selective UV-B filter with little activity against UV-A wavelengths. In vitro, ensulizole oxidizes guanine bases upon photoexcitation by UV-B and may cause photodamage on DNA, proteins and lipids in the cellular context .

Metabolism

Not Available