2-Phenoxyethanol
Synonym(s):PHE;2-Phenoxyethanol;PhG;Ethylene glycol monophenyl ether;DOWANOL EPh
- CAS NO.:122-99-6
- Empirical Formula: C8H10O2
- Molecular Weight: 138.16
- MDL number: MFCD00046644
- EINECS: 204-589-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-04 16:27:49
What is 2-Phenoxyethanol?
Toxicity
LC50 oral, rat; 1980 mg/kg . LD50 Rabbit dermal 2250 mg/kg.
2-Phenoxyethanol (PhE) has been shown to induce hepatotoxicity, renal toxicity, and hemolysis at dosages ≥ 400 mg/kg/day in subchronic and chronic studies in multiple species.
The major hazards encountered in the use and handling of 2-phenoxyethanol stem from its toxicologic properties. Toxic by all routes (inhalation, ingestion, and dermal contact), exposure to this very faintly aromatic, colorless, oily liquid may occur from its use.
Description
2-Phenoxyethanol, known early on as ethylene glycol monophenyl ether, is a high-boiling, oily liquid that is moderately water-soluble. It has a long history and several uses in chemical manufacturing and consumer products.
The Uses of 2-Phenoxyethanol
Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Background
Phenoxyethanol is a colorless liquid with a pleasant odor. It is a glycol ether used as a perfume fixative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in fish aquaculture. Phenoxyethanol is an ether alcohol with aromatic properties. It is both naturally found and manufactured synthetically. Demonstrating antimicrobial ability, phenoxyethanol acts as an effective preservative in pharmaceuticals, cosmetics and lubricants.
Pharmacokinetics
This substance has broad-spectrum antimicrobial activity against bacteria, yeasts, and mold .
Metabolism
The fate of phenoxyethanol in rats and humans has been investigated . The rate of intestinal absorption was rapid, with 60-70% of the excreted (14)C detected at 3 hours and > 95% of the total 4-day urinary (14)C detected within the first 24 hr. Trace amounts of radioactivity were detected in feces. Four days after dosing, only trace amounts of radioactivity remained in the carcass, primarily in the liver (< 0.2% of the dose), fat and muscle. At the 4 day point, the (14)C concentration in blood was measured to be only 0.001 .
The major metabolite of phenoxyethanol is phenoxyacetic acid .
Properties of 2-Phenoxyethanol
Melting point: | 11-13 °C (lit.) |
Boiling point: | 247 °C (lit.) |
Density | 1.102 g/mL at 25 °C (lit.) |
Flash point: | >230 °F |
storage temp. | Store below +30°C. |
solubility | soluble, clear, colorless to very faintly yellow |
form | Liquid |
appearance | colorless, oily liquid |
color | Clear colorless |
Odor | Faint aromatic odor |
Water Solubility | 30 g/L (20 ºC) |
Safety information for 2-Phenoxyethanol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-Phenoxyethanol
InChIKey | QCDWFXQBSFUVSP-UHFFFAOYSA-N |
Abamectin manufacturer
AMINES AND PLASTICIZERS LTD.
Rsum Industries Pvt. Ltd.
Murli Krishna Exports Pvt Ltd
Venus Ethoxyethers Pvt Ltd
Viswaat Chemicals Limited
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