2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

Synonym(s):2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid;4-Chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-benzoic acid

CAS NO.：99754-06-0
Empirical Formula: C21H22ClNO3
Molecular Weight: 371.86
MDL number: MFCD00210755
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 13:31:19

2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID Structural

What is 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID?

Description

ONO-RS-082 (99754-06-0) is a reversible inhibitor of Ca2+-independent phospholipase A2?(PLA2), IC50=7 μM for guinea pig lung PLA2.1?Inhibits epinephrine-induced thromboxane production in platelets.1?Inhibition of PLA2?by ONO-RS-032 disrupts endosome tubule formation and maintenance of the Golgi complex.2-4?Prevents Xenopus oocyte maturation at stage V.5

The Uses of 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

ONO-RS-082 is a potent PLA2 and epinephrine inhibitor.ONO-RS-082 is a phospholipase inhibitor.

What are the applications of Application

ONO-RS-082 is a potent PLA2 and epinephrine inhibitor

in vitro

previous study found that human platelets stimulated by epinephrine led to enhanced turnover of phosphatidylinositol 4,5-bisphosphate, accumulated inositol trisphosphate, diacylglycerol, and phosphatidic acid, indicating stimulation of phospholipase c. it was shown that these responses could be completely blocked by inhibitors of alpha 2-adrenergic receptors including ono-rs-082 or removal of fibrinogen. in addition, epinephrine could evoked an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that was inhibited by ono-rs-082 or the absence of fibrinogen. moreover, it was found that ono-rs-082 at 3.5 μm was able to inhibit epinephrine-stimulated thromboxane production in human platelets. ono-rs-082 could also disrupt endosome tubule formation and maintenance of the golgi complex [1].

References

1) Banga?et al.?(1986),?Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine; Proc. Natl. Acad. Sci. USA?83?9197 2) De Figueiredo?et al. (2001),?Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists; J. Biol. Chem.?276?47361 3) Schmidt?et al. (2010),?A role for phospholipase A2 activity in membrane tubule formation and TGN trafficking; Traffic?11?1530 4) Bechler and Brown (2014),?Gβ1γ2 activates phospholipase A2-dependent Golgi membrane tubule formation; Front. Cell. Dev. Biol.?28?0004 5) Islam?et al.?(2005),?The distinct stage-specific effects of 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid on the activation of MAP kinase and Cdc2 kinase in Xenopus oocyte maturation; Cell Signal.?17?507

Properties of 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

Melting point:	175-177℃
storage temp.	room temp
solubility	DMSO: ≥20mg/mL
form	powder
color	white
Sensitive	Light Sensitive
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety information for 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P501:Dispose of contents/container to..…