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HomeProduct name list2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

Synonym(s):2H-Furo[2,3-h]-1-benzopyran-2-one;2-Oxo-(2H)-furo(2,3-h)-1-benzopyran;Isopsoralen;NSC 404563

  • CAS NO.:523-50-2
  • Empirical Formula: C11H6O3
  • Molecular Weight: 186.16
  • MDL number: MFCD00064930
  • EINECS: 637-055-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran Structural

What is 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran?

Description

Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (-) bacteria. It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC50 = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta. Angelicin also weakly inhibits topoisomerase II (IC50 = 404 μM).

Chemical properties

White Solid

The Uses of 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

Antifungal

What are the applications of Application

Angelicin is an antifungal

Definition

ChEBI: Angelicin is a furanocoumarin.

Synthesis Reference(s)

Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O

Clinical Use

Angelicin derivatives are used to treat psoriasis and cancer. One way of treating these diseases is by photochemotherapy (PUVA) which combines UV irradiation with photosensitizing chemical. Also, it was shown that it is actively inhibits the synthesis of nucleic acids in tumor cells thereby decreasing their growth.

Properties of 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

Melting point: 132-134°C
Boiling point: 104°C/4mmHg(lit.)
Density  1.2477 (rough estimate)
refractive index  1.6310 (estimate)
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form  neat
form  Solid
color  White
λmax 302nm(EtOH)(lit.)
BRN  153970
CAS DataBase Reference 523-50-2(CAS DataBase Reference)
NIST Chemistry Reference 2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2)
IARC 3 (Vol. 40, Sup 7) 1987

Safety information for 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran

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