2-Oxazolidone

CAS NO.：497-25-6
Empirical Formula: C3H5NO2
Molecular Weight: 87.08
MDL number: MFCD00005268
EINECS: 207-840-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 2-Oxazolidone ?

Chemical properties

off-white to yellow-beige crystals or powder

The Uses of 2-Oxazolidone

As an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).

The Uses of 2-Oxazolidone

An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).

Definition

ChEBI: An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise it from *benzene, dichloroethane, CHCl3 or EtOH. It is a cyclic urethane, and as such it is not very stable. [Katritzky et al. J Chem Soc Perkin II 145 1990, Beilstein 27 H 135, 27 II 259, 27 III/IV 2516.]

Properties of 2-Oxazolidone

Melting point:	83-87 °C(lit.)
Boiling point:	220 °C48 mm Hg(lit.)
Density	1.2736 (rough estimate)
refractive index	1.4940 (estimate)
Flash point:	220°C/48mm
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly, Heated), Methanol (Slightly)
form	Crystals or Powder
pka	12.78±0.20(Predicted)
color	Off-white to yellow-beige
Water Solubility	Soluble in water.
BRN	106251
CAS DataBase Reference	497-25-6(CAS DataBase Reference)
NIST Chemistry Reference	Oxazolidin-2-one(497-25-6)
EPA Substance Registry System	2-Oxazolidinone (497-25-6)

Safety information for 2-Oxazolidone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.