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HomeProduct name list2'-O-MOE-A(Bz)-3'-phosphoramidite

2'-O-MOE-A(Bz)-3'-phosphoramidite

  • CAS NO.:251647-53-7
  • Empirical Formula: C50H58N7O9P
  • Molecular Weight: 932.01
  • MDL number: MFCD29472587
  • Update Date: 2024-10-23 13:36:13
2'-O-MOE-A(Bz)-3'-phosphoramidite Structural

What is 2'-O-MOE-A(Bz)-3'-phosphoramidite?

Description

2'-O-MOE-A(Bz)-3'-phosphoramidite, also known as DMT-2'-O-MOE-rA(Bz) phosphoramidite, inserts 2'-O-methoxyethyl-modified adenosine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation. It is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

Chemical properties

The IUPAC name of 2'-O-MOE-A(Bz)-3'-phosphoramidite is (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It is white to off-white powder.

The Uses of 2'-O-MOE-A(Bz)-3'-phosphoramidite

N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators.

Properties of 2'-O-MOE-A(Bz)-3'-phosphoramidite

pka 7.87±0.43(Predicted)
form  Solid
color  White to off-white

Safety information for 2'-O-MOE-A(Bz)-3'-phosphoramidite

Computed Descriptors for 2'-O-MOE-A(Bz)-3'-phosphoramidite

InChIKey VPBYBQBHLYRLHG-VCCSSPGHNA-N

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