2’-O-Methyl-rA(N-Bz)phosphoramidite
Synonym(s):DMT-2′-O-Me-rA(bz) amidite;N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- CAS NO.：110782-31-5
- Empirical Formula: C48H54N7O8P
- Molecular Weight: 887.96
- MDL number: MFCD00792622
- EINECS: 200-100-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-10 09:00:29
What is 2’-O-Methyl-rA(N-Bz)phosphoramidite?
Chemical properties
White or off-white power
The Uses of 2’-O-Methyl-rA(N-Bz)phosphoramidite
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a nucleotide used in the synthesis of native-like crosslinked duplex RNA.
General Description
Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentary DNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules
Properties of 2’-O-Methyl-rA(N-Bz)phosphoramidite
| Melting point: | 93-95°C |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 7.87±0.43(Predicted) |
| color | white to off-white |
Safety information for 2’-O-Methyl-rA(N-Bz)phosphoramidite
Computed Descriptors for 2’-O-Methyl-rA(N-Bz)phosphoramidite
| InChIKey | AZCGOTUYEPXHMJ-DCATYJMPNA-N |
2’-O-Methyl-rA(N-Bz)phosphoramidite manufacturer
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