2-Nitroanisole
Synonym(s):1-Methoxy-2-nitrobenzene
- CAS NO.:91-23-6
- Empirical Formula: C7H7NO3
- Molecular Weight: 153.14
- MDL number: MFCD00007096
- EINECS: 202-052-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is 2-Nitroanisole?
Chemical properties
yellow to amber liquid
Chemical properties
2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
The Uses of 2-Nitroanisole
2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
The Uses of 2-Nitroanisole
2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
Definition
ChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
Production Methods
Methanolic sodium hydroxide is added slowly to a solution of 2- chloronitrobenzene in methanol at 70 ℃; the mixture is then heated gradually to 95 ℃ under pressure to complete the reaction. After dilution with water the product 2-Nitroanisole is separated as an oil, in 90 % yield, and methanol is recovered from the aqueous layer.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4501, 1988 DOI: 10.1016/S0040-4039(00)80531-6
General Description
2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
Hazard
Questionable carcinogen.
Safety Profile
Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
Potential Exposure
A dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
Carcinogenicity
o-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Purify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
Incompatibilities
A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures >110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide + zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
Waste Disposal
Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Properties of 2-Nitroanisole
Melting point: | 9-12 °C (lit.) |
Boiling point: | 273 °C (lit.) |
Density | 1.254 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Refrigerator, Under Inert Atmosphere |
solubility | alcohol: soluble(lit.) |
form | Oil |
Specific Gravity | 1.254 |
color | Pale Yellow |
Water Solubility | 1.45 g/L (20 ºC) |
Merck | 14,6584 |
BRN | 1868032 |
Dielectric constant | 43.0 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 91-23-6(CAS DataBase Reference) |
IARC | 2A (Vol. 65, 127) |
NIST Chemistry Reference | Benzene, 1-methoxy-2-nitro-(91-23-6) |
EPA Substance Registry System | o-Nitroanisole (91-23-6) |
Safety information for 2-Nitroanisole
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H350:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 2-Nitroanisole
2-Nitroanisole manufacturer
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