2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

CAS NO.：391211-97-5
Empirical Formula: C13H7F3INO2
Molecular Weight: 393.1
MDL number: MFCD08690072
EINECS: 809-435-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-27 11:02:23

What is 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid?

Chemical properties

Off-White Solid

The Uses of 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

Intermediate in the preparation of MEK inhibitors.

Synthesis

To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.

Properties of 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

Melting point:	189-191°C
Boiling point:	370.1±42.0 °C(Predicted)
Density	1.939±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	3.25±0.36(Predicted)
color	Off-White to Beige

Safety information for 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.