2-MONOPALMITIN
- CAS NO.:23470-00-0
- Empirical Formula: C19H38O4
- Molecular Weight: 330.5
- MDL number: MFCD00058513
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:13
What is 2-MONOPALMITIN?
Description
2-Arachidonoyl glycerol (2-AG; ) is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.
Chemical properties
White Solid
The Uses of 2-MONOPALMITIN
A biomarker of metabolic responses to hepatotoxicants and carcinogens.
What are the applications of Application
2-Palmitoylglycerol is a fatty acid glycerol ester that enhances 2-arachidonoylglycerol
Definition
ChEBI: A 2-monoglyceride where the acyl group is hexadecanoyl (palmitoyl).
Biological Activity
Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol ((5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester ). Does not bind to CB 1 or CB 2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.
Properties of 2-MONOPALMITIN
Melting point: | 68-70°C |
Boiling point: | 387.92°C (rough estimate) |
Density | 0.9708 (rough estimate) |
refractive index | 1.4434 (estimate) |
storage temp. | −20°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
form | neat |
pka | 13.54±0.10(Predicted) |
form | Solid |
color | White to Off-White |
BRN | 1796692 |
Safety information for 2-MONOPALMITIN
Computed Descriptors for 2-MONOPALMITIN
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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