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HomeProduct name list2-MONOPALMITIN

2-MONOPALMITIN

2-MONOPALMITIN Structural

What is 2-MONOPALMITIN?

Description

2-Arachidonoyl glycerol (2-AG; ) is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.

Chemical properties

White Solid

The Uses of 2-MONOPALMITIN

A biomarker of metabolic responses to hepatotoxicants and carcinogens.

What are the applications of Application

2-Palmitoylglycerol is a fatty acid glycerol ester that enhances 2-arachidonoylglycerol

Definition

ChEBI: A 2-monoglyceride where the acyl group is hexadecanoyl (palmitoyl).

Biological Activity

Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol ((5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester ). Does not bind to CB 1 or CB 2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

Properties of 2-MONOPALMITIN

Melting point: 68-70°C
Boiling point: 387.92°C (rough estimate)
Density  0.9708 (rough estimate)
refractive index  1.4434 (estimate)
storage temp.  −20°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form  neat
pka 13.54±0.10(Predicted)
form  Solid
color  White to Off-White
BRN  1796692

Safety information for 2-MONOPALMITIN

Computed Descriptors for 2-MONOPALMITIN

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