2-Methylindoline
Synonym(s):α-Methyldihydroindole;2,3-Dihydro-2-methylindole;2-Methyl-2,3-dihydroindole;NSC 65598
- CAS NO.：6872-06-6
- Empirical Formula: C9H11N
- Molecular Weight: 133.19
- MDL number: MFCD00005706
- EINECS: 229-971-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:56:26
What is 2-Methylindoline?
Chemical properties
CLEAR YELLOW TO BROWN LIQUID
The Uses of 2-Methylindoline
2-Methylindoline is an intermediate in the production of various indole derivatives
The Uses of 2-Methylindoline
Reactant for preparation of:
- Inhibitors of NOD1-induced nuclear factor-κB activation
- Red fluorescent dyes for organic light-emitting diodes
- Norepinephrine reuptake inhibitors
- MT2-selective melatonin receptor antagonists
- Protease-activated receptor-1 antagonists
- Diuretic agent indapamide
- Dopamine D2/D4 receptor antagonists
- Antitumor agents
Definition
ChEBI: 2-Methylindoline is a member of indoles.
Synthesis Reference(s)
Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056
Chemical and Pharmaceutical Bulletin, 26, p. 108, 1978 DOI: 10.1248/cpb.26.108
Properties of 2-Methylindoline
| Melting point: | -51 °C |
| Boiling point: | 228-229 °C (lit.) |
| Density | 1.023 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 200 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | Liquid |
| pka | 5.26±0.40(Predicted) |
| Specific Gravity | 1.02 |
| color | Clear yellow to brown |
| Water Solubility | negligible |
| CAS DataBase Reference | 6872-06-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Methylindoline(6872-06-6) |
| EPA Substance Registry System | 1H-Indole, 2,3-dihydro-2-methyl- (6872-06-6) |
Safety information for 2-Methylindoline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H311:Acute toxicity,dermal H319:Serious eye damage/eye irritation H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methylindoline
New Products
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