2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Synonym(s):5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine;Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
- CAS NO.：265312-55-8
- Empirical Formula: C15H12N2O2S
- Molecular Weight: 284.33
- MDL number: MFCD09971103
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
![2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Structural](https://img.chemicalbook.in/CAS/GIF/265312-55-8.gif)
What is 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE?
The Uses of 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Ryuvidine is an antifungal agent used against pathogenic fungi.
What are the applications of Application
Cdk4 Inhibitor III is a cell-permeable, selective Cdk4 inhibitor
Definition
ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.
General Description
A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Store at +4°C
Properties of 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
| Boiling point: | 463.8±45.0 °C(Predicted) |
| Density | 1.416±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | Soluble to 20 mM in DMSO and to 5 mM in ethanol |
| pka | -1.63±0.20(Predicted) |
| form | Black-purple solid |
| color | Brown to black |
Safety information for 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
Computed Descriptors for 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
New Products
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