2-Methyl-4-nitrophenol

CAS NO.：99-53-6
Empirical Formula: C7H7NO3
Molecular Weight: 153.14
MDL number: MFCD01734013
EINECS: 202-763-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:07:02

What is 2-Methyl-4-nitrophenol?

Chemical properties

white crystals

The Uses of 2-Methyl-4-nitrophenol

2-Methyl-4-nitrophenol is suitable as a target compound in the study on measurement of methylnitrophenol concentrations and stable isotope ratios in the atmospheric particulate matter and as an internal standard in the determination of monoaromatic nitro compounds in atmospheric aerosols using high performance liquid chromatography electrospray tandem mass spectrometry (HPLC/ESI-MS/MS) method.
It may be used as starting material in the synthesis of 2-bromo-4-nitro-6-methylphenol.

Preparation

2-methyl-4-nitrophenol is prepared by the reaction of 2-methyl-4-nitroaniline with sodium hydroxide and hydrochloric acid.

General Description

2-Methyl-4-nitrophenol is a nitrophenol derivative. The study of its crystal structure reveals the molecule to be nearly planar. Its synthesis has been reported. FT-IR and FT-Raman spectra and molecular modeling of 2-methyl-4-nitrophenol have been analyzed. It is reported to be one of the compounds in diesel exhaust particles (DEP) that shows potential vasodilatation activity in rats. Its reduction catalyzed by porous carbon-encapsulated gold nanoparticles has been investigated.

Properties of 2-Methyl-4-nitrophenol

Melting point:	93-98 °C(lit.)
Boiling point:	266.03°C (rough estimate)
Density	1.2744 (estimate)
refractive index	1.5744 (estimate)
storage temp.	Inert atmosphere,Room Temperature
form	Solid
pka	7.43±0.22(Predicted)
color	Off-White
InChI	InChI=1S/C7H7NO3/c1-5-4-6(8(10)11)2-3-7(5)9/h2-4,9H,1H3
CAS DataBase Reference	99-53-6(CAS DataBase Reference)
EPA Substance Registry System	Phenol, 2-methyl-4-nitro- (99-53-6)

Safety information for 2-Methyl-4-nitrophenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.