2-Methyl-4-isothiazolin-3-one hydrochloride

Synonym(s):Methylisothiazolinone hydrochloride;MIT

CAS NO.：26172-54-3
Empirical Formula: C4H6ClNOS
Molecular Weight: 151.61
MDL number: MFCD06804636
EINECS: 247-499-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-23 14:28:52

2-Methyl-4-isothiazolin-3-one hydrochloride Structural

What is 2-Methyl-4-isothiazolin-3-one hydrochloride?

The Uses of 2-Methyl-4-isothiazolin-3-one hydrochloride

2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.

What are the applications of Application

Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

General Description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

storage

store at 2°C - 8°C,close container well.

Properties of 2-Methyl-4-isothiazolin-3-one hydrochloride

Density	1.551 at 21℃
vapor pressure	0.777-1Pa at 20-25℃
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
BRN	3993054
Stability:	Hygroscopic
CAS DataBase Reference	26172-54-3(CAS DataBase Reference)
EPA Substance Registry System	3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3)

Safety information for 2-Methyl-4-isothiazolin-3-one hydrochloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.