2-Mercaptothiazoline
Synonym(s):2-Mercapto-2-thiazoline;2-Mercaptothiazoline;2-Thiazoline-2-thiol
- CAS NO.:96-53-7
- Empirical Formula: C3H5NS2
- Molecular Weight: 119.21
- MDL number: MFCD00126013
- EINECS: 202-512-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is 2-Mercaptothiazoline?
Chemical properties
white to beige fine crystalline powder
The Uses of 2-Mercaptothiazoline
2-Mercaptothiazoline is an antithyroid agent that strongly reduces thyroid hormone levels. 2-Mercaptothiazoline is also used as an intermediate in the preparation of pesticides and other biologically active compounds.
The Uses of 2-Mercaptothiazoline
medicament.;medical agent; brightening agent
The Uses of 2-Mercaptothiazoline
2-Mercaptothiazoline, is used in the chain-lengthening of alkyl halides by trans-iodopropenylenation. 2-Mercaptothiazoline is an antithyroid agent that strongly reduces thyroid hormone levels. 2-Mercaptothiazoline is also used as an intermediate in the preparation of biologically active compounds. It is also used as a tool for highly selective chiral synthesis of penam- and carbapenam-type β-lactam antibiotics.
What are the applications of Application
2-Thiazoline-2-thiol is a tool for highly selective chiral syntheses of penam- and carbapenam-type β-lactam antibiotics
Purification Methods
Purify the thiol by dissolution in aqueous alkali, precipitation by addition of HCl and then recrystallisation from H2O (as needles). [IR: Flett J Chem Soc 347 1953 and Mecke et al. Chem Ber 90 975, Gabriel & Stelzner Chem Ber 28 2931 1895, Beilstein 27 III/IV 2540.]
Properties of 2-Mercaptothiazoline
Melting point: | 100-105 °C(lit.) |
Boiling point: | 176-178 °C(Press: 0.25 Torr) |
Density | 1.235 (estimate) |
refractive index | 1.4826 (estimate) |
storage temp. | Store below +30°C. |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | 13.01±0.20(Predicted) |
form | Fine Crystalline Powder |
color | White to beige |
PH | 6-7 (10g/l, H2O, 20℃) |
Water Solubility | SOLUBLE IN HOT WATER |
BRN | 106332 |
CAS DataBase Reference | 96-53-7(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Thiazolidinethione(96-53-7) |
EPA Substance Registry System | 2-Thiazolidinethione (96-53-7) |
Safety information for 2-Mercaptothiazoline
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 2-Mercaptothiazoline
InChIKey | WGJCBBASTRWVJL-UHFFFAOYSA-N |
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