2-Iodopyridine
- CAS NO.:5029-67-4
- Empirical Formula: C5H4IN
- Molecular Weight: 205
- MDL number: MFCD00464928
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-26 12:09:49
What is 2-Iodopyridine?
Chemical properties
Light yellow liquid
The Uses of 2-Iodopyridine
2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
The Uses of 2-Iodopyridine
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Reactions
2-Iodopyridine and 3-alkoxy-2-iodopyridines are oxidized by DMDO to give PyIO2 , which serve as oxidants for alcohols and sulfides.
In palladium-catalyzed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine were coupled with CO and various primary and secondary amines. The biologically relevant N-substituted nicotinamides and 3-pyridyl-glyoxylamides were obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The chemoselectivity towards the ketoamide can be increased by the elevation of CO pressure. On the other hand, N-alkyl and N-aryl-carboxamides were obtained exclusively from CO pressure of 1 to 90 bar by using 2-iodopyridine and iodopyrazine.
Pd-catalyzed aminocarbonylation of 2-iodopyridine and 3-iodopyridine with primary and secondary amines.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6
General Description
2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
Properties of 2-Iodopyridine
Melting point: | 118-120℃ |
Boiling point: | 52 °C (lit.) |
Density | 1.928 g/mL at 25 °C (lit.) |
refractive index | n |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
pka | pK1:1.82(+1) (25°C) |
form | Solid |
color | Pale yellow |
Water Solubility | Slightly soluble in water. |
Sensitive | Light Sensitive |
CAS DataBase Reference | 5029-67-4(CAS DataBase Reference) |
Safety information for 2-Iodopyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Iodopyridine
InChIKey | CCZWSTFVHJPCEM-UHFFFAOYSA-N |
Abamectin manufacturer
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin G Tubulysin M (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2,2-diethoxyethanethioamide 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 4-Bromo-N,N-bis(4-iodophenyl)aniline 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-Chlorophenyl)piperidin-2-one 4-(Azidomethyl)-3-chloropyridine 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2-chloro-N-(biphenyl-2-yl) nicotinamide 4-bromo-2,5-difluoro benzoic acid 5-Bromo-4,6-difluoro-2,3-dihydro-1h-indoleRelated products of tetrahydrofuran
You may like
-
5029-67-4 2-IODOPYRIDINE 98%View Details
5029-67-4 -
5029-67-4 98%View Details
5029-67-4 -
2-Iodopyridine 98%View Details
5029-67-4 -
2-Iodopyridine (stabilized with Na2S2O3) CAS 5029-67-4View Details
5029-67-4 -
2-Iodopyridine, 98% CAS 5029-67-4View Details
5029-67-4 -
2-Iodopyridine CAS 5029-67-4View Details
5029-67-4 -
6390-09-6View Details
6390-09-6 -
6-Bromo indoleView Details