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HomeProduct name list5-Bromo-2-hydroxymethylpyridine

5-Bromo-2-hydroxymethylpyridine

  • CAS NO.:88139-91-7
  • Empirical Formula: C6H6BrNO
  • Molecular Weight: 188.02
  • MDL number: MFCD04035597
  • EINECS: 618-116-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-30 21:22:42
5-Bromo-2-hydroxymethylpyridine Structural

What is 5-Bromo-2-hydroxymethylpyridine?

Chemical properties

Light yellow Cryst

Synthesis

5-bromo-2-pyridinecarboxylic acid, methyl ester (648mg, 3mmol) in 10ml of methanol was slowly added to sodium borohydride (340mg, 9mmol) in an ice bath. After that, the ice bath was removed and the reaction mixture was warmed to room temperature. The reaction was stirred for 12 hours. Then 1N HCl was added to adjust the pH to 1. Afterward, a saturated sodium bicarbonate solution was added to adjust the pH to 8. The mixture was then extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. This resulted in the formation of 535mg of white solid, which was identified as 5-bromo-2-pyridinemethanol. The yield of the desired product was 94.8%.
2-Hydroxymethyl-5-bromopyridine

Properties of 5-Bromo-2-hydroxymethylpyridine

Melting point: 59-60°C
Boiling point: 0°C
Density  1.668±0.06 g/cm3(Predicted)
Flash point: 0°C
storage temp.  Inert atmosphere,Room Temperature
form  powder to crystal
pka 13.09±0.10(Predicted)
color  White to Light yellow to Light orange
InChI InChI=1S/C6H6BrNO/c7-5-1-2-6(4-9)8-3-5/h1-3,9H,4H2
CAS DataBase Reference 88139-91-7(CAS DataBase Reference)

Safety information for 5-Bromo-2-hydroxymethylpyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 5-Bromo-2-hydroxymethylpyridine

InChIKey RUCZFWMEACWFER-UHFFFAOYSA-N
SMILES C1(CO)=NC=C(Br)C=C1

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