2-Hydroxybenzyl alcohol
Synonym(s):2-Hydroxybenzyl alcohol;Salicyl alcohol;Saligenin;Saligenine, Salicyl alcohol
- CAS NO.：90-01-7
- Empirical Formula: C7H8O2
- Molecular Weight: 124.14
- MDL number: MFCD00004617
- EINECS: 201-960-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-07 19:09:42
What is 2-Hydroxybenzyl alcohol?
Chemical properties
light brown crystalline powder
Chemical properties
Salicyl alcohol: (saligenin, o-hydroxy benzyl alcohol) crystallizes from water in the form of needles or white rhombic crystals. It occurs in nature as the bitter glycoside, salicin CAS: 138-52-3, which is isolated from the bark of Salix helix, S. pentandra, S. praecos, some other species of willow trees, and the bark of a number of species of poplar trees such as Polpulus balsamifera, P. candicans, and P. nigra.
The Uses of 2-Hydroxybenzyl alcohol
2-Hydroxybenzyl Alcohol is a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect. Also It is an intermediate in the production of phenol formaldehyde res ins (may remain after condensation of the resin); sensitizer in phenol-formaldehyde resins; in loeal anesthetics.
The Uses of 2-Hydroxybenzyl alcohol
anesthetic (local), antiinflammatory
Definition
ChEBI: A hydroxybenzyl alcohol that is phenol substituted by a hydroxymethyl group at C-2.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 5314, 1995 DOI: 10.1021/jo00121a060
Tetrahedron Letters, 10, p. 1739, 1969
General Description
2-Hydroxybenzyl alcohol participates in the selective ring opening reaction of 4H-1,3,2-benzodioxasilines.
Contact allergens
Methylol phenols are sensitizers contained in resins based on phenol and formaldehyde of the resol type. Cross-reactivity is possible with other phenol derivative molecules.
Purification Methods
Crystallise saligenine from water or EtOH/*C6H6 (m 89o). [Beilstein 6 III 4537, 6 IV 5896.]
Properties of 2-Hydroxybenzyl alcohol
| Melting point: | 83-85 °C(lit.) |
| Boiling point: | 190.92°C (rough estimate) |
| Density | 1,613 g/cm3 |
| refractive index | 1.5035 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow |
| pka | pK1:9.92 (25°C) |
| form | Crystalline Flakes or Powder |
| color | Light beige |
| Water Solubility | 67 g/L (22 ºC) |
| Merck | 14,8325 |
| BRN | 1907195 |
| Stability: | Stable. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents. |
| CAS DataBase Reference | 90-01-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Salicyl alcohol(90-01-7) |
| EPA Substance Registry System | 2-Hydroxybenzenemethanol (90-01-7) |
Safety information for 2-Hydroxybenzyl alcohol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Hydroxybenzyl alcohol
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