2-HYDROXY-5-METHYLBENZOPHENONE

CAS NO.：1470-57-1
Empirical Formula: C14H12O2
Molecular Weight: 212.24
MDL number: MFCD00002379
EINECS: 216-002-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is 2-HYDROXY-5-METHYLBENZOPHENONE?

Chemical properties

yellow crystalline powder

The Uses of 2-HYDROXY-5-METHYLBENZOPHENONE

2-?Hydroxy-?5-?methylbenzophenone is a general reagent used in the synthesis of anti-bacterial and anti-fungal agents.

Preparation

Preparation by condensation of benzotrichloride with p-cresol,
? in the presence of aluminium chloride in carbon disulfide for 2 h (75%). The 6,12-diphenyl-2,8-dimethyl-6,12-epoxy-6H,12H-dibenzo[b,f] dioxocin, an intermediate compound, was also formed under these conditions (29%). This “dioxocin”, by hydrolysis with concentrated sulfuric acid at r.t., gave the expected ketone (91%);
? in the presence of aqueous sodium hydroxide in a water bath for 4 h (33%) or in 32–40% aqueous sodium hydroxide at 70–80° (67%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1924, 1973 DOI: 10.1021/jo00950a030

Properties of 2-HYDROXY-5-METHYLBENZOPHENONE

Melting point:	83-85 °C (lit.)
Boiling point:	312.08°C (rough estimate)
Density	1.1035 (rough estimate)
refractive index	1.6000 (estimate)
pka	8.24±0.43(Predicted)
form	powder to crystal
color	Light orange to Yellow to Green
CAS DataBase Reference	1470-57-1(CAS DataBase Reference)

Safety information for 2-HYDROXY-5-METHYLBENZOPHENONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.