2-Hydroxy-5-methyl-3-nitropyridine
- CAS NO.：7464-14-4
- Empirical Formula: C6H6N2O3
- Molecular Weight: 154.12
- MDL number: MFCD02070021
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-03 14:56:00
What is 2-Hydroxy-5-methyl-3-nitropyridine?
Description
2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is an organosynthetic compound that can be used as a feedstock for the synthesis of other compounds or as a biological inhibitor, such as in the preparation of 2-chloro-5-methyl-3-nitropyridine and transglutaminase 2 (tg2) inhibitors. It reacts with molybdenum and chloride. It is able to react with molybdenum and chloride, and it is able to increase the reaction yield and time. It is also used to explain its reactivity with xylene.
Chemical properties
Powder or crystalline
The Uses of 2-Hydroxy-5-methyl-3-nitropyridine
2-Hydroxy-5-methyl-3-nitropyridine may be used in the preparation of 2-chloro-5-methyl-3-nitropyridine via chlorination, using thionyl chloride. It may also be used is preparing proteasome inhibitors containing 5-methylpyridin-2(1H)-one moiety.
Properties of 2-Hydroxy-5-methyl-3-nitropyridine
| Melting point: | 179 °C (dec.) (lit.) |
| Boiling point: | 353.3±35.0 °C(Predicted) |
| Density | 1.24 g/mL at 25 °C(lit.) |
| Flash point: | 179 °C |
| storage temp. | 2-8°C |
| solubility | soluble in Dimethylformamide |
| pka | 8.78±0.10(Predicted) |
| form | powder to crystal |
| color | White to Yellow |
| CAS DataBase Reference | 7464-14-4(CAS DataBase Reference) |
Safety information for 2-Hydroxy-5-methyl-3-nitropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Hydroxy-5-methyl-3-nitropyridine
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