2'-Hydroxy-4'-methylacetophenone

CAS NO.：6921-64-8
Empirical Formula: C9H10O2
Molecular Weight: 150.17
MDL number: MFCD00100559
EINECS: 230-040-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is 2'-Hydroxy-4'-methylacetophenone?

The Uses of 2'-Hydroxy-4'-methylacetophenone

2′-Hydroxy-4′-methylacetophenone is found in Angelica koreana roots and a study was done in which it could be useful for natural acaricides against three mite species.

Preparation

Preparation by treatment of methyl 4-hydroxy-7- methyl-coumarin-3-carboxylate with potassium hydroxide at 200° (87%).

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4183, 1996 DOI: 10.1016/0040-4039(96)00790-3

General Description

2′-Hydroxy-4′-methylacetophenone, also known as 1-(2-hydroxy-4-methylphenyl)ethanone can be synthesized by the Fries rearrangement of m-tolyl acetate in the presence of zirconium tetrachloride. The results from the toxicity studies on mite species suggest that 2′-hydroxy-4′-methylacetophenone possesses acaricidal property.

Properties of 2'-Hydroxy-4'-methylacetophenone

Melting point:	21°C
Boiling point:	245 °C(lit.)
Density	1.08 g/mL at 25 °C(lit.)
refractive index	n20/D 1.565(lit.)
Flash point:	>230 °F
storage temp.	2-8°C
form	clear liquid
pka	10.27±0.10(Predicted)
color	Colorless to Light orange to Yellow
λmax	325nm(MeOH)(lit.)
CAS DataBase Reference	6921-64-8(CAS DataBase Reference)
EPA Substance Registry System	Ethanone, 1-(2-hydroxy-4-methylphenyl)- (6921-64-8)

Safety information for 2'-Hydroxy-4'-methylacetophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.