3'-(Trifluoromethyl)acetophenone

Synonym(s):3-Acetylbenzotrifluoride

CAS NO.：349-76-8
Empirical Formula: C9H7F3O
Molecular Weight: 188.15
MDL number: MFCD00000391
EINECS: 206-490-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-01 13:52:05

3'-(Trifluoromethyl)acetophenone Structural

What is 3'-(Trifluoromethyl)acetophenone?

Chemical properties

CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID

The Uses of 3'-(Trifluoromethyl)acetophenone

3''-?(Trifluoromethyl)?acetophenone is a reagent used in the stabilization of endosomal-toll-like receptor TRL8 creating a sort of inhibitory activity.

General Description

Asymmetric catalytic addition of ethyl groups to 3′-(trifluoromethyl)acetophenone catalyzed by ligands derived from trans-1,2-diaminocyclohexane and camphor sulfonyl chloride has been reported. Phenylation of 3′-(trifluoromethyl)acetophenone in the presence of dihydroxy bis(sulfonamide) ligand (enantioselective catalyst), titanium tetraisopropoxide and diphenylzinc has been investigated.

Properties of 3'-(Trifluoromethyl)acetophenone

Boiling point:	198-200 °C(lit.)
Density	1.235 g/mL at 25 °C(lit.)
vapor pressure	35Pa at 25℃
refractive index	n20/D 1.4611(lit.)
Flash point:	183 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Red to Green
Specific Gravity	1.235
Water Solubility	620mg/L at 25℃
BRN	640151
CAS DataBase Reference	349-76-8(CAS DataBase Reference)
NIST Chemistry Reference	3-CF3-C6H4-COCH3(349-76-8)
EPA Substance Registry System	Ethanone, 1-[3-(trifluoromethyl)phenyl]- (349-76-8)

Safety information for 3'-(Trifluoromethyl)acetophenone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.