2-Fluorobenzoyl chloride

CAS NO.：393-52-2
Empirical Formula: C7H4ClFO
Molecular Weight: 158.56
MDL number: MFCD00000656
EINECS: 206-887-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 2-Fluorobenzoyl chloride?

Chemical properties

clear colorless to faintly colored liquid

The Uses of 2-Fluorobenzoyl chloride

2-Fluorobenzoyl Chloride (cas# 393-52-2) is a compound useful in organic synthesis.

The Uses of 2-Fluorobenzoyl chloride

2-Fluorobenzoyl chloride has been used in the preparation of 3-(N-Hydroxycarbamimidoyl)-benzoic acid methyl ester. It has been used to develop an hollow-fiber liquid phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.

General Description

Colorless liquid.

Air & Water Reactions

Decomposes in water to form HCl with generation of heat

Reactivity Profile

2-Fluorobenzoyl chloride is sensitive to moisture. Incompatible with water, alcohol, bases (including amines) and with oxidizing agents . May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Fire Hazard

2-Fluorobenzoyl chloride is combustible.

Properties of 2-Fluorobenzoyl chloride

Melting point:	4 °C (lit.)
Boiling point:	90-92 °C/15 mmHg (lit.)
Density	1.328 g/mL at 25 °C (lit.)
refractive index	n20/D 1.536(lit.)
Flash point:	180 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly)
form	Liquid
Specific Gravity	1.328
color	Clear colorless to faintly colored
Water Solubility	Decomposition
Sensitive	Lachrymatory
BRN	636864
CAS DataBase Reference	393-52-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzoyl chloride, 2-fluoro-(393-52-2)
EPA Substance Registry System	o-Fluorobenzoyl chloride (393-52-2)

Safety information for 2-Fluorobenzoyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.