2-Biphenylcarboxylic acid
Synonym(s):2-Phenylbenzoic acid
- CAS NO.：947-84-2
- Empirical Formula: C13H10O2
- Molecular Weight: 198.22
- MDL number: MFCD00002463
- EINECS: 213-432-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-Biphenylcarboxylic acid?
Chemical properties
2-Biphenylcarboxylic acid is White powder
The Uses of 2-Biphenylcarboxylic acid
2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists.
The Uses of 2-Biphenylcarboxylic acid
It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product.
Synthesis Reference(s)
The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015
Purification Methods
Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.]
Properties of 2-Biphenylcarboxylic acid
| Melting point: | 111-113 °C(lit.) |
| Boiling point: | 199 °C10 mm Hg(lit.) |
| Density | 1.1184 (rough estimate) |
| refractive index | 1.5954 (estimate) |
| Flash point: | 343-344°C |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 3.46(at 25℃) |
| color | White to beige |
| Water Solubility | insoluble |
| BRN | 974075 |
| CAS DataBase Reference | 947-84-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Biphenylcarboxylic acid(947-84-2) |
Safety information for 2-Biphenylcarboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Biphenylcarboxylic acid
| InChIKey | ILYSAKHOYBPSPC-UHFFFAOYSA-N |
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
Biphenyl-2-carboxylic Acid CAS 947-84-2View Details
947-84-2 -
2033-24-1 98%View Details
2033-24-1 -
1975-50-4 98%View Details
1975-50-4 -
2-HYDROXY BENZYL ALCOHOL 98%View Details
90-01-7 -
2-Chloro-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 221615-75-4 98%View Details
221615-75-4 -
61397-56-6 CIS BROMO BENZOATE 98%View Details
61397-56-6 -
14714-50-2 (2-Hydroxyphenyl)acetonitrile 98+View Details
14714-50-2 -
118753-70-1 98+View Details
118753-70-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.