2'-DEOXY-L-CYTIDINE
- CAS NO.:40093-94-5
- Empirical Formula: C9H13N3O4
- Molecular Weight: 227.22
- MDL number: MFCD02683609
- EINECS: 500-100-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-19 17:35:41
What is 2'-DEOXY-L-CYTIDINE?
Description
Torcitabine (b-L-2u-deoxycytidine) (L-dC) is the b-L-enantiomer of the natural nucleoside D-cytidine. The drug is currently under development by Idenix as an antiviral agent for the treatment of chronic hepatitis B virus infection. Torcitabine has poor oral bioavailability, but its 3u,5u-divaline ester (val-L-dC) and the 3u-monovaline ester, valtorcitabine dihydrochloride, have excellent oral bioavailability and consequently the torcitabine prodrug, valtorcitabine, has replaced torcitabine in clinical development.
The Uses of 2'-DEOXY-L-CYTIDINE
Torcitabine and its prodrug, valtorcitabine, are investigational drugs being developed solely for the treatment of chronic HBV infection. Torcitabine itself has undergone preliminary phase I/II clinical trials in HBeAg-positive patients, initially as the 3u,5u-divalyl prodrug in escalating doses of 50, 100, 200, and 400 mg/day, but later as the more stable monovaline ester form, valtorcitabine dihydrochloride, and administered to four cohorts in doses of 300, 600, 900, and 1200 mg/ day for 28 days.
Properties of 2'-DEOXY-L-CYTIDINE
Boiling point: | 497.6±55.0 °C(Predicted) |
Density | 1.73±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO: 250 mg/mL (1100.26 mM) |
pka | 14.03±0.60(Predicted) |
form | Solid |
color | White to off-white |
Water Solubility | Water: 250 mg/mL (1100.26 mM) |
Safety information for 2'-DEOXY-L-CYTIDINE
Computed Descriptors for 2'-DEOXY-L-CYTIDINE
New Products
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