2-Chloroquinoline

CAS NO.：612-62-4
Empirical Formula: C9H6ClN
Molecular Weight: 163.6
MDL number: MFCD00006741
EINECS: 210-317-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2-Chloroquinoline?

Chemical properties

white to yellowish crystals, powder, chunks or

The Uses of 2-Chloroquinoline

2-Chloroquinoline is an intermediate used in the synthesis of various compounds that exhibits antifungal properties.

The Uses of 2-Chloroquinoline

2-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. It reacts with benzotriazole, followed by cyclization with loss of nitrogen, gives the indolo[2,3-b]quinoline ring system for use in novel cytotoxic DNA topoisomerase II inhibitors.

Synthesis Reference(s)

The Journal of Organic Chemistry, 67, p. 7884, 2002 DOI: 10.1021/jo016196i
Synthesis, p. 1013, 1987 DOI: 10.1055/s-1987-28152

Purification Methods

Purify it by crystallisation of its picrate to constant melting point (123-124o) from *benzene, regenerating the base and distilling it under vacuum [Cumper et al. J Chem Soc 1183 1962]. 2-Chloroquinoline can be crystallised from EtOH. Its picrate has m 123-124o (from EtOH). [Beilstein 20 H 359, 20/7 V 312.]

Properties of 2-Chloroquinoline

Melting point:	34-37 °C (lit.)
Boiling point:	266-267 °C (lit.)
Density	1.23 g/mL at 25 °C (lit.)
refractive index	1.6342 (estimate)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	methanol: 0.1 g/mL, clear
pka	0.41±0.40(Predicted)
form	Crystalline Powder, Crystals and/or Chunks or Fused Mass
color	White to yellow
Water Solubility	Insoluble
BRN	112561
CAS DataBase Reference	612-62-4(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 2-chloro-(612-62-4)
EPA Substance Registry System	Quinoline, 2-chloro- (612-62-4)

Safety information for 2-Chloroquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.