2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
- CAS NO.:65836-72-8
- Empirical Formula: C11H14ClNO3
- Molecular Weight: 243.69
- MDL number: MFCD01733639
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:42
What is 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE?
Biological Activity
DKM 2-93 is a relatively selective UBA5 inhibitor with IC50 value of 430 μM.
in vitro
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
in vivo
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
Properties of 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
Melting point: | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
Boiling point: | 425.7±45.0 °C(Predicted) |
Density | 1.194±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : ≥ 150 mg/mL (615.54 mM) |
form | Solid |
pka | 13.42±0.46(Predicted) |
color | White to light yellow |
Safety information for 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation H341:Germ cell mutagenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
New Products
Tubulysin C Tubulysin H Tubulysin I 4,4-DIFLUOROCYCLOHEXANAMINE 1-(1,1-Difluoroethyl)-2-fluorobenzene 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE CYCLOBUTYLAMINE HYDROCHLORIDE 3-Aminocyclobutanone hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
1-(CHLOROACETYL)-5-[4-(DIFLUOROMETHOXY)-3-METHOXYPHENYL]-3-THIEN-2-YL-4,5-DIHYDRO-1H-PYRAZOLE
N-[4-(BENZYLOXY)-3-METHOXYBENZYL]-2-CHLOROACETAMIDE
2-CHLORO-1-(6,7-DIMETHOXY-1-PHENYL-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANONE
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)-N-METHYLACETAMIDE
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
1-(CHLOROACETYL)-2-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)PYRROLIDINE
2-CHLORO-N-[1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ETHYL]ACETAMIDE
2-CHLORO-N-METHYL-N-(2,3,4-TRIMETHOXYBENZYL)ACETAMIDE
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