2-Chloro-4,6-dimethoxy-1,3,5-triazine

CAS NO.：3140-73-6
Empirical Formula: C5H6ClN3O2
Molecular Weight: 175.57
MDL number: MFCD00075607
EINECS: 221-541-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-08 11:27:59

What is 2-Chloro-4,6-dimethoxy-1,3,5-triazine?

Chemical properties

white to almost white crystalline powder

The Uses of 2-Chloro-4,6-dimethoxy-1,3,5-triazine

2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.

The Uses of 2-Chloro-4,6-dimethoxy-1,3,5-triazine

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

What are the applications of Application

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable peptide coupling agent

General Description

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

Properties of 2-Chloro-4,6-dimethoxy-1,3,5-triazine

Melting point:	71-74 °C (lit.)
Boiling point:	99-100 °C (1 mmHg)
Density	1.7917 (rough estimate)
vapor pressure	5.8Pa at 25℃
refractive index	1.5870 (estimate)
Flash point:	99-100°C/1mm
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
pka	0.33±0.10(Predicted)
form	Crystalline Powder
color	White to almost white
Water Solubility	insoluble
BRN	148988
CAS DataBase Reference	3140-73-6(CAS DataBase Reference)

Safety information for 2-Chloro-4,6-dimethoxy-1,3,5-triazine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.