2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER

Synonym(s):1-Ethyl oxalyl chloride 2-oxime

off-white solid

Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:

in the preparation of (+)-and (?)-Δ²-isoxazolines
in the synthesis of CIP-AS (?), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptors
to generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonate
to prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines

Melting point:	70-76 °C (lit.)
Boiling point:	230.5±23.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	soluble in Methanol
form	powder to crystal
pka	7.60±0.10(Predicted)
color	White to Almost white
Sensitive	Moisture Sensitive/Lachrymatory
BRN	606193
CAS DataBase Reference	14337-43-0(CAS DataBase Reference)

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.