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HomeProduct name list2-Benzofurancarboxylic acid ethyl ester

2-Benzofurancarboxylic acid ethyl ester

Synonym(s):Benzofuran-2-carboxylic acid ethyl ester

2-Benzofurancarboxylic acid ethyl ester Structural

What is 2-Benzofurancarboxylic acid ethyl ester?

The Uses of 2-Benzofurancarboxylic acid ethyl ester

Ethyl Coumarilate has been used as a reactant for the preparation of benzofuropyridines that have a high affinity for the α2-adrenoceptor.

Preparation

Synthesis of ethyl benzofuran-2-carboxylate: Salicylaldehyde (20.0 mL, 0.164 mol) and diethyl bromomalonate (40.0 mL, 0.168 mol) in ethyl methyl ketone (40.0 mL, 0.555 mol) was treated with anhydrous potassium carbonate (20.0 g,0.869 mol). The reaction mixture was refluxed for 18 h on steam bath. Ethyl methyl ketone was distilled off under reduced pressure and the residue formed was dissolved in 400 mL of water and cooled in an ice-bath. It was acidified with dil H2SO4. The product formed was extracted with 25 mL portion of solvent ether twice and the extract was washed with sodium bicarbonate solution. It was dried over calcium chloride. Solvent was removed and the residue ethyl benzofuran-2-carboxylate was dried.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 6315, 1986 DOI: 10.1016/S0040-4039(00)87796-5

Properties of 2-Benzofurancarboxylic acid ethyl ester

Melting point: 166-170℃
Boiling point: 105°/0.1mm
Density  1.1656
refractive index  1.5640 (estimate)
Flash point: >110℃
storage temp.  2-8°C
CAS DataBase Reference 3199-61-9(CAS DataBase Reference)

Safety information for 2-Benzofurancarboxylic acid ethyl ester

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Benzofurancarboxylic acid ethyl ester

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