(2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Synonym(s):(2-Aminophenyl)-carbamic acid tert-butyl ester;Mono-N-Boc-o-phenylenediamine

CAS NO.：146651-75-4
Empirical Formula: C11H16N2O2
Molecular Weight: 208.26
MDL number: MFCD02169707
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

(2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER Structural

What is (2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER?

Chemical properties

White Solid

The Uses of (2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Protected 1,2-Phenyldiamine, an intermediate in the synthesis of histone deacetylase agents and antitumor agents.

What are the applications of Application

tert-butyl 2-aminophenylcarbamate is an intermediate in the synthesis of histone deacetylase agents and antitumor agents

Purification Methods

Purify the ester by crystallisation from CHCl3/hexane (1:1, v/v) and dry it in vacuo. [Seto et al. J Am Chem Soc 115 1321 1993, Seto et al. J Am Chem Soc 127 11442 2005.]

Properties of (2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Melting point:	109-114 °C
Boiling point:	280.6±23.0 °C(Predicted)
Density	1.152±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	13.47±0.70(Predicted)
color	Light Yellow

Safety information for (2-AMINO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.