2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- CAS NO.:335031-01-1
- Empirical Formula: C6H7BrN2O
- Molecular Weight: 203.04
- MDL number: MFCD05664025
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is 2-Amino-5-bromo-3-(hydroxymethyl)pyridine?
The Uses of 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).
Properties of 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
Melting point: | 137-140°C |
Boiling point: | 343.5±37.0 °C(Predicted) |
Density | 1.766±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | Acetone, Ethyl Acetate, Methanol |
form | Solid |
pka | 13.16±0.10(Predicted) |
color | Off-white to yellow |
CAS DataBase Reference | 335031-01-1(CAS DataBase Reference) |
Safety information for 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
New Products
Tubulysin D Tubulysin I Tubulysin G (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate CYCLOBUTYLAMINE HYDROCHLORIDE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROCYCLOHEXANAMINE 2,2-Difluoropropylamine hydrochloride Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8